Manufacturing, like other industries, is rising to the challenges imposed by aggressive consumer demands and the need for cost-effective processing that delivers quality in the fastest possible time. Fierce competition means that keeping abreast of new developments and applications in technology is essential if companies are to meet demands profitably and keep ahead of competitors. This book investigates the design and management of digital manufacturing and assembly systems for an efficient, flexible, and modular production of customized products using the I40 (industry 4.0)-enabling technologies. This book will also provide case studies covering modeling, simulation, and optimization.